Lamivudine for the treatment of membranous glomerulopathy
Membranous glomerulopathy (MGN) is a well-recognized extrahepatic manifestation of chronic infection with the hepatitis B virus (HBV). The pathogenesis of this association is unclear, but immune...
View ArticleLamivudine for the treatment of membranous glomerulopathy: CASE PRESENTATIONS...
A 46-year-old Chinese man, known to be a chronic HBV carrier, presented in March 1999 with peripheral edema and abdominal swelling. His serum albumin was 13 g/L and a 24 h urine collection revealed 7.1...
View ArticleLamivudine for the treatment of membranous glomerulopathy: CASE PRESENTATIONS...
In June 2002, the serum ALT rose to three times ULN. HBeAg remained negative, but HBV DNA was detected at a level of 9.4 pg/mL (Hybrid Capture 2, Digene Corporation, USA). The patient was asymptomatic...
View ArticleLamivudine for the treatment of membranous glomerulopathy: CASE PRESENTATIONS...
A 44-year-old Chinese woman, who was known to be a HBV carrier, presented in October 1998 with ankle edema. Subsequent investigations revealed nephrotic range proteinuria (16.6 g/day), microscopic...
View ArticleLamivudine for the treatment of membranous glomerulopathy: DISCUSSION (1)
HBV has long been known to be associated with a variety of glomerulardiseases including membranous glomerulonephritis, membranoproliferative glomerulonephritis and mesangial proliferative...
View ArticleLamivudine for the treatment of membranous glomerulopathy: DISCUSSION (2)
The natural history of HBV-related glomerulopathy has been collected from case series in both children and adults. Wong et al retrospectively identified 18 pediatric cases in Hong Kong, in which 78% of...
View ArticleLamivudine for the treatment of membranous glomerulopathy: DISCUSSION (3)
The results oftreatmentof HBV-relatedMGN have been variable. Although there are controlled trials of corticosteroids in adults with idiopathicMGN, there have been no controlled studies in...
View ArticleLamivudine for the treatment of membranous glomerulopathy: DISCUSSION (4)
Lamivudine is a pyrimidine nucleoside analogue that interrupts hepatitis B viral replication. The drug is well-tolerated and usually results in a significant reduction of HBV DNA levels. However, HBeAg...
View ArticleLamivudine for the treatment of membranous glomerulopathy: DISCUSSION (5)
The exact impact of lamivudine in our two patients is unclear. The first patient had a prompt HBeAg seroconversion, which resulted in an improvement in his nephrotic syndrome, although he continues to...
View ArticleLamivudine for the treatment of membranous glomerulopathy: CONCLUSION
Lamivudine appears to be a potentially safe and effective means of treating adults with glomerular diseaseassociated with HBV. Lamivudine should be considered a potential alternative to interferon for...
View Article
